Diabetic Hypertensive Leptin Receptor–Deficient db/db Mice Develop Cardioregulatory Autonomic Dysfunction
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چکیده
منابع مشابه
Diabetic cardiac autonomic dysfunction: parasympathetic versus sympathetic.
BACKGROUND Diabetic cardiac autonomic dysfunction often causes lethal arrhythmia and sudden cardiac death. 123I-Metaiodobenzylguanidine (MIBG) can evaluate cardiac sympathetic dysfunction, and analysis of heart rate variability (HRV) can reflect cardiac parasympathetic activity. We examined whether cardiac parasympathetic dysfunction assessed by HRV may correlate with sympathetic dysfunction as...
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PURPOSE Dysfunction of endothelial nitric oxide synthase (eNOS) has been implicated in the pathogenesis of diabetic vascular complications. This study was undertaken to determine the role of eNOS in the development of diabetic retinopathy (DR), by investigating the functional consequences of its deficiency in the diabetic state. METHODS Diabetes was induced in eNOS-knockout (eNOS(-/-)) and C5...
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Autonomic neuropathies are normally subclinical in diabetic children and adolescents, but in poorly controlled patients may be extremely symptomatic [1]. Gastrointestinal (GI) autonomic dysfunction may include esophageal dysmotility, gastroparesis, dysfunction of intestinal neurons, and decreased/absence of gastrocolic reflex [1, 2]. We report a case of a diabetic boy who had a severe GI dysaut...
متن کاملMeasures of Autonomic Dysfunction in Diabetic and Idiopathic Gastroparesis
BACKGROUND Gastroparesis is a condition classically characterized by delayed gastric emptying and is associated with considerable morbidity. While the etiology of gastroparesis remains elusive, autonomic dysfunction may play an important role, especially as many patients with gastroparesis also have diabetes. The aim of this study was to determine whether measures of autonomic function differ b...
متن کاملCardioregulatory Mechanism
Coronary vascular endothelial cells release substances into the coronary circulation that modify the contractile system of cardiac myocytes, and cardiac myocytes may release factors that modulate the secretion of cardioregulatory substances by endothelial cells. This regulatory loop is sensitive to the rate of coronary flow and tissue oxygen tension. In the present study, coronary venous efflue...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2009
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.108.124776